Summary: A new system for high-density EEG helps with the imaging of the origin and path of both normal and abnormal neural activity.

Source: NIH

Understanding the source and network of signals as the brain functions is a central goal of brain research. Now, Carnegie Mellon engineers have created a system for high-density EEG imaging of the origin and path of normal and abnormal brain signals.

Bin He, head of the Carnegie Mellon University’s Department of Biomedical Engineering, and colleagues are working on a core initiative of the National Institutes of Health, called Brain Research through Advancing Innovative Neurotechnologies (BRAIN).

The group’s work with high-density EEG, reported in the journal Nature Communications, takes a major step toward realizing one of the central goals of the BRAIN initiative: “produce a revolutionary new dynamic picture of the brain that, for the first time, shows how individual cells and complex neural circuits interact in both time and space.” In other words, develop a way to watch how the brain does what it does.

“Electroencephalography (EEG), has been used for decades to track brain signals,” explained Shumin Wang, Ph.D., director of the NIBIB program in Bio-Electromagnetic Technologies. “Dr. He and his team developed a more powerful, high-density version of EEG that can track brain signals across much larger areas of the brain than previously possible. Artificial intelligence is then used to identify where these stronger signals originate and travel through the brain, with great accuracy.”

The research team tested the high-density EEG system in patients with epilepsy. Individuals experience seizures caused by errant pulses of brain activity, known as the epileptogenic zone. Many patients’ seizures can be controlled with medications. For those who are medication-resistant, surgically removing the epileptogenic zone is a clinical option. The ability of high-density EEG to accurately identify the epileptic source would allow for much-improved brain surgeries to efficiently remove only the problem area and spare surrounding brain tissue.

The team tested their method, termed FAST-IRES for spatio-temporal iteratively reweighted edge sparsity, on 36 epilepsy patients undergoing pre-operative testing. FAST-IRES non-invasive brain recordings were obtained over several days using a special high-density EEG array. The fact that FAST-IRES is non-invasive is extremely important, given that the standard pre-operative testing requires invasive EEG, which is necessary to pinpoint the epileptogenic region but comes with increased risks of infection, complications, and costs.

Brain signals are measured with high-density EEG. The signal source is simulated and estimated using artificial intelligence. Results are validated with clinical findings. Image is credited to Carnegie Mellon University College of Engineering.

 

Across the 36 patients, the FAST-IRES method analyzed more than 1000 EEG spikes and 86 seizures occurred. The high-density recordings were then analyzed using the artificial intelligence piece of the FAST-IRES method and compared with the standard invasive EEG pre-operative testing and the surgical findings.

The FAST-IRES method was extremely accurate in identifying the position and extent of the epileptogenic zone in the patients, which was confirmed with the surgical data. “Our results clearly demonstrated that FAST-IRES could identify the epileptogenic zone with high precision, using non-invasive high-density EEG scalp recordings,” said He. Collaborators on the study at the Mayo clinic are considering implementing the system in the future.

The team believes the FAST-IRES technique could be used for diagnosis and treatment of Alzheimer’s, Parkinson’s, stroke and even depression. “It is extremely satisfying to see our work make a significant impact in fulfilling one of the central goals of the BRAIN initiative,” said He. “In addition to treating patients, we look forward to our work helping researchers make significant advances in our understanding of human neuroscience.”

About this neuroscience research article

Source:
NIH
Media Contacts:
Press Office – NIH
Image Source:
The image is credited to Carnegie Mellon University College of Engineering.

Original Research: Open access
“Noninvasive electromagnetic source imaging of spatiotemporally distributed epileptogenic brain sources”. by Abbas Sohrabpour et al.
Nature Communications doi:10.1038/s41467-020-15781-0

For more articles like this please sign up for our eTips by liking us on Facebook and giving us your email for our Newsletter.

  • This field is for validation purposes and should be left unchanged.

Tags: , , , , , ,

What Our Clients Are Saying

Julia W

Teachers made huge comments on his math skills and behavior. I also saw this at home with understanding of what I said to him registering more with him. I saw this in his eyes: recognition. Fewer outbursts of anger.

Anita M

I am extremely happy with my son’s outcomes and feel very fortunate to have encountered Dr. Bonesteel early in my child’s life. This method has dramatically changed his ability to focus and take initiative. I feel confident that my son’s life has been dramatically enhanced. I can’t express my appreciation fully in words.

Mary B

Dr. Bonesteel has masterfully, compassionately, and extremely kindly helped me navigate through a history of childhood and marital abuse, a child with twenty years of struggle with life-threatening physical and emotional illness, extended family discord, and disharmony with my child with severe depression. I am blessed to have found Neurohealth Associates.

Byron

Overall, excellent experience. Very happy with Dr B and staff is wonderful. We feel like we have our family life back!

Phil

I am very thankful this technology was available for my training. I was extremely satisfied with all aspects of my training protocols.

Our
Latest
Posts

SEE ALL POSTS

STAY UP TO DATE

with the latest news and information regarding neurofeedback and brain health.